Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
نویسندگان
چکیده
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2014